Endocrine Abstracts

Cancer cells have shown an overexpressed fructose transporter GLUT5 and preferential utilization of fructose as compared to glucose, implicating that a fructose-based analogue would be a useful target for diagnosis and treatment of cancer. We have successfully synthesized the fructose conjugated-gefitinib compounds {N-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxy-quinazolin-6-yl]-4- [N-methyl-N-(1-deoxy-1-fructosyl)]aminobutanamide}, and examined its antitumor effic...

Background: Type 2 diabetic (T2D) patients have alterations in the gut microbiota composition, compared to healthy individuals. Such alterations may play a role in the pathogenesis of T2D and insulin resistance. Bifidobacteria and Lactobacillus are among the most predominant bacteria found in human gut. They can also easily be added in probiotic preparations, thus making them ideal agents for therapeutic interventions. In this study, we aimed to determine if there were alterat...